What the CRISPR Embryo Editing Study Really Taught Us

  • Added:  6 days ago
  • What did the recent study using the CRISPR gene editing technique actually entail, and what did we learn from it?

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    Sources:

    www.nature.com/nature/journal/vaop/ncurrent/pdf/nature23305.pdf
    www.nature.com/nature/journal/vaop/ncurrent/full/nature23533.html
    www.nature.com/news/crispr-fixes-disease-gene-in-viable-human-embryos-1.22382
    www.clinicaltrials.gov/ct2/show/NCT02793856?term=NCT02793856&rank=1
    www.wired.com/story/first-us-crispr-edited-embryos-suggest-superbabies-wont-come-easy/
    www.mayoclinic.org/diseases-conditions/hypertrophic-cardiomyopathy/home/ovc-20122102
    www.nature.com/news/first-crispr-clinical-trial-gets-green-light-from-us-panel-1.20137
    www.newscientist.com/article/2133095-boom-in-human-gene-editing-as-20-crispr-trials-gear-up/
    www.heart.org/HEARTORG/Conditions/More/Cardiomyopathy/Hypertrophic-Cardiomyopathy_UCM_444317_Article.jsp#.WYj4rojyuM8

    Images:

    en.wikipedia.org/wiki/File:Crispr.png
  • EducationEducation
  • Runtime: 6:05
  • SciShow  science  Hank  Green  education  learn  designer babies  embryo  Genetically engineering  fertilized eggs  uterus  IVF  in vitro fertilization  MYBPC3  DNA  CRISPR  Cas9  gene  marker  sequencing  template  sperm  hypertrophic cardiomyopathy  gene editing technique  human genetic engineering  RNA  

Comments: 1 453

  • matt knowles
    matt knowles 7 hours ago

    But we will get designer babies eventually right? I want a glowing toddler damn it

  • Christopher Teale
    Christopher Teale 8 hours ago

    Does anyone else think that experimenting with embryos is the same as experimenting on people? What happened to the embrios after they where studied? Merely discarded? That may not look human to the naked eye, but that doesn't mean it isn't one. I love science, but human rights should not be violated in its name

  • Mel Tee
    Mel Tee Day ago

    I'm actually excited about designer babies and I hope society realizes how much of an advantage it could be to our future offspring.

  • Kenshino
    Kenshino Day ago

    If they can cure a disease then they can make humans stronger and better.

  • kangourouuu1
    kangourouuu1 3 days ago

    Why do we talk about "designer babies" and not "designed babies"? When I hear the former, I can't help but see a smug baby with a tiny mustache, a weird haircut, pinched mouth, trying to prove me their scrambled mess of a garbage-made clothing is art worth millions.

  • Victor Muwonge
    Victor Muwonge 3 days ago

    Really need this to work.
    With sickle cell anemia, this w would be a big help to myself and others like me At least if anything for the future generation.

    Why can't we use retro viruses as vectors since they can easily get into the DNA ? Is there no way to to weaken e.g HIV then put in the gene we want and change the mismatch that causes sickle cell anemia?

  • Beorn
    Beorn 3 days ago

    We need to panic! If we don't we're failing our 24 hour news cycle system. Panic! Panic! And especially be fearful of Science. Or anyone with any kind of advanced education. Are we going to ignore all the scientific conspiracies? Climate Change. Vaccinations. Evolution. Moon landings. Please people ... you're not paying attention! Science, education, etc. is bad. And we need to acknowledge that! Anyone remember them being exposed here? www.cc.com/video-clips/x1h7ku/the-daily-show-with-jon-stewart-weathering-fights---science--what-s-it-up-to-

  • Praise Kek
    Praise Kek 3 days ago

    Can CRISPR still work on people that have already been born?

  • MrSab177
    MrSab177 3 days ago

    Meh. I'll just wait for the AI to figure everything out for us. Why trouble ourselves?

  • Alexis
    Alexis 3 days ago

    this stuff always reminds me of the movie GATACCA

  • Slagon Drayer
    Slagon Drayer 3 days ago

    If our genome protects itself from changes that proves we are a simulation.

  • Jace Ortega
    Jace Ortega 3 days ago

    Why is there hair around my anus????

  • Blarghenschnarf
    Blarghenschnarf 3 days ago

    Why don't plants get sunburn and cancer all the time?

  • Ryan Martinez-Ukulele lessons

    Blasphemy!

  • E S
    E S 3 days ago +8

    These breakthroughs in medicine are total game-changers. If you're curious and like learning, come join a live chat with scientists on the future of health and progress in rejuvenation biotechnology: discord.gg/ftSbffu

  • Cassio Ruggeri Cons
    Cassio Ruggeri Cons 3 days ago

    Great, now I have @acapellascience's song stuck in my head again.

  • Vincent Hondius
    Vincent Hondius 3 days ago

    You guys really need to work on your sound levels. Every video has a different loudness

  • Christopher Mockford

    My sister died exactly 18 years ago from hypertrophic cardiomyopathy. I don't want that gene continued to be passed on, and am not sure which side it was inherited from, not knowing whether my surviving sister or I have passed it on. I also have a friend who was diagnosed with it, but has survived into adulthood and has two daughters, who hopefully don't have it. I'm more than ready and willing to modify my genes to not pass on any bad genes.

  • Zom Bee Nature
    Zom Bee Nature 4 days ago

    So if the mother's DNA is faulty then it might "repair" introduced good DNA to the faulty DNA version? That really sucks...
    Everyone, please watch my tiny nature videos. There is no talking in them. It is hard to find quiet places to record. Shhh!

  • Annabelle The Alpaca

    That's a crisp lasagna

  • Thomas Fisher
    Thomas Fisher 4 days ago

    You guys ever watch Gattaka?

  • Melinda H
    Melinda H 4 days ago

    I wish this worked on full humans. I want to genetically engineer myself to be one of those people who can eat whatever they want and never exercise, but still stay skinny

  • USAball
    USAball 4 days ago

    Can we Crispred a plant that grows an iPhone as a flower if we edit it hard enough?

  • ABetterWeapon
    ABetterWeapon 4 days ago

    This is all well and good, but how long will it be, until I get retractable claws?

  • The Idiot Reviewer
    The Idiot Reviewer 4 days ago

    there goes humanity chance of being super intelligent via genetic engineering.. to the path of being dumb shall we resume..

  • Persephonetoo
    Persephonetoo 4 days ago

    Pictures of what is being discussed would help people process this information better. Interesting ideas, though. :-)

  • William Sevy
    William Sevy 4 days ago +1

    Humans were never meant to play God.

    • Kody Ballard
      Kody Ballard 2 days ago

      Just A Person the fact that there's no proof of any existence of God, is proof he doesn't exist, I could say that there is a giant fat sky poodle who created the earth but that a anorexic elephant cat created the rest of the world, and I'd be completely accurate in saying that because as you said "there is no reliable proof for or against [my fat sky poodle and my anorexic elephant cat], so you cannot prove or disprove the existence of [my fat sky poodle and my anorexic elephant cat]"
      ironic how you change god to anything else and that argument sounds just plain stupid......... maybe because there is no fat sky poodle and there is no "god"
      as for reliable proof against god, there's the fact of Dinosaurs existing millions of years before humans, evolution, and the fact that we've dated the planet and found that it's much older then what the Bible said it is


    • Just A Person
      Just A Person 2 days ago

      There is no reliable proof for or against God, so you cannot prove or disprove the existence of God.


    • Kody Ballard
      Kody Ballard 3 days ago

      the existence of god isn't debatable, there are ZERO FACTS to prove it's existence, god is not real, you can believe whatever you want, just know its not real and that real world science shouldn't be held accountable to works of fiction


    • William Sevy
      William Sevy 3 days ago

      Kody Ballard the existence of God is debatable but I believe in a God.


    • Kody Ballard
      Kody Ballard 4 days ago

      William Sevy good thing Humans aren't and that God doesn't exist


  • Zipi damn
    Zipi damn 4 days ago

    Gene for radiation resistance like in cockroaches when? The Solar System isn't gonna colonize itself, lads.

    • NotaWalrus
      NotaWalrus 4 days ago

      It's a bit more complicated than that.


  • Jessica Spaetzel
    Jessica Spaetzel 4 days ago

    Since we are all pro science here and we watch this channel to learn more about science, I have questions. What happens to the embryos from the trials? Do they become "less perfect" lab grown babies or are they disposed of in biohazardous waste bins? Is it against the hippocratic oath to grow these babies when they will most likely live a shortened lifespan? What are the morals and ethics at hand for human interference to dna on the molecular level beyond what artificial selection could have ever done?

    • NotaWalrus
      NotaWalrus 4 days ago

      Probably they just dump them out. In principle there shouldn't be anything imperfect about them and could be implanted into a mother as is done with in vitro fertilization.


  • Christian Shammami
    Christian Shammami 4 days ago +2

    GATTACA?

  • Naama Weiss
    Naama Weiss 4 days ago

    PGD FTW!!! My daughter is a PGD baby!
    Can't wait for crisper to be a thing we ca use on our next baby

  • Roger
    Roger 4 days ago +1

    We can't treat having babies as having a designer dog

  • madscientistshusta
    madscientistshusta 4 days ago

    May i take your order
    Me:yes i will take 1 aryian baby with extra blue eyes to go.





    Just kidding i acually have high hopes for genetic engineering.

  • Ileen Rauqel
    Ileen Rauqel 4 days ago

    If anyone has read the chemical Gardens trilogy then I think this might turn ugly but.. I'm in support of this I'm just weary because of this series! Y'all should google it fr gives you chills lol

  • dont blame the aussiebloke

    I imagine there will be a kind of butterfly effect from gm entering our gene pool.
    Zombie apocalypse is still on the cards

  • Podimann
    Podimann 4 days ago +1

    Well that's disappointing. I was hoping for genetically engineered humans sooner rather than later.

  • LM_84
    LM_84 4 days ago

    abort all babies with giant xenomorph like heads

  • Iacon Dawnshire
    Iacon Dawnshire 4 days ago

    One step closer to curing baldness \o/

  • NeonGlocKz FTW
    NeonGlocKz FTW 4 days ago +2

    I want a baby with a 12 inch pecker

  • medanman62
    medanman62 4 days ago

    Scishow on trending!!!

  • APE KONG GAMER
    APE KONG GAMER 4 days ago +1

    This is messed up.what do the researchers do with all the human beings used for their experiments?

    • Kody Ballard
      Kody Ballard 4 days ago

      APE KONG GAMER and to answer your earlier question, no it's not messed up, two people donated dna for scientific research, all cells are "alive", so the concept that when a egg and sperm meet they then become alive is false all you did was create a complete(as in all 23 chromosomes) cell than will then begin to divide and replicate, embryo cells at the stage the research was done at aren't human beings just human cells


    • Kody Ballard
      Kody Ballard 4 days ago

      APE KONG GAMER pretty sure I know what happens hence the Microbiology degree on my wall, these fertilized eggs aren't human beings yet, at this point there literally nothing more then a couple cells dividing rapidly to form cellular mass which then begins to develop organs and organs systems and eventually is born as a human being at the embryo stage there nothing more then cells


    • APE KONG GAMER
      APE KONG GAMER 4 days ago

      Kody Ballard i suggest that you google what happens when an egg is fertilized


    • Kody Ballard
      Kody Ballard 4 days ago

      they aren't human beings, there just cells, take a biology class please


    • APE KONG GAMER
      APE KONG GAMER 4 days ago

      Tdangerously somebody jerked off and somebody donated their eggs. when sperm meets an egg the egg becomes fertilized thus creating life. The life of these fertilized eggs is terminated once the scientists are done with them. You don't find that messed up?


  • David Heller
    David Heller 4 days ago

    Build a Elysium machine

  • Do R/C!
    Do R/C! 4 days ago +1

    Hopefully eventually we can use this kind of technology to counteract the absolute slaughtering we have given natural selection.

  • Bender Rodriguez
    Bender Rodriguez 4 days ago +1

    www. fantucci. com

  • siegfried greding
    siegfried greding 4 days ago

    He's thinking too linearly. Just wait and see what this can do in the near future

  • TessellatedGuy
    TessellatedGuy 4 days ago

    People who oppose this hate one thing and one thing only...

    People who are gonna be objectively better than them in every way.

  • Jonathon Dupont
    Jonathon Dupont 4 days ago

    Totally blacked out in the middle of the video.

  • Shau Hame
    Shau Hame 4 days ago

    the only real concern i see with genetic engineering is making people more obedient, or more prone to being a beliver, etc.... In short making them more likely to obey you.

    • Shau Hame
      Shau Hame 4 days ago

      so yeah we're a long way away from that.


  • Knight Robot
    Knight Robot 4 days ago +1

    We could engineer humans like the alien moves and make them perfect gods.

  • Daniel Swagman
    Daniel Swagman 4 days ago +1

    Editing human embryos is dispicable and evil.

    • Kody Ballard
      Kody Ballard 4 days ago

      Daniel Swagman and your rational behind that comment is?


  • dude
    dude 4 days ago +1

    who the hell?

  • Jessica Castrillon
    Jessica Castrillon 4 days ago

    I wonder if scientists can figure how to get the DNA to accept the donor DNA during repair, that would be interesting. Maybe they can "CRISPR/cas9 it" (donor DNA) into the egg cell first somehow, before inserting the sperm and cas9 enzyme. Then we can utilize the mechanism that the sperm and egg cells naturally use to repair DNA in a different way. Wish I could fully grasp the science behind this; I think it's so interesting!

  • John Smith
    John Smith 4 days ago

    Honestly, if I ever become a father, I would like my child to be a perfect as possible. I would not want to pass on my bad eyesight and depression.

  • Forget Yourself
    Forget Yourself 4 days ago +1

    "and everything's good" ahhh science.

  • venomjuker
    venomjuker 4 days ago

    Woah woah woah Designer babies?! Though im a freethinker but imma just say let god play god not humans.

    • Kody Ballard
      Kody Ballard 4 days ago

      venomjuker well humans made God, sooo............ think we can do whatever we want to do


    • Knight Robot
      Knight Robot 4 days ago

      venomjuker They are biological mechanisms that can all be perfectly explained through science. There is no third party controlling it


    • venomjuker
      venomjuker 4 days ago

      Knight Robot god creates things and editing what god is creating is like just playing god ourselves.


    • Knight Robot
      Knight Robot 4 days ago

      venomjuker why does god matter? Everything is just determined by genes.


  • gamerking419780
    gamerking419780 4 days ago +1

    I call using cas9 as a username

  • lonnie smith
    lonnie smith 4 days ago

    pig man

  • AdventurerBen The Pro

    It is either genetic engineering to have healthier kids, or be overbearing parents who only allow their kids to love athletes to get healthier great great great great great great... ...grandkids, which would take longer.

  • kenny Doherty
    kenny Doherty 5 days ago +1

    I'm a microbio major at auburn we've been learning about this system for a while. Very cool to see it finally getting the attention it deserves

    • Kody Ballard
      Kody Ballard 4 days ago

      kenny Doherty omg dude, same!!!! Microbiology major from Cal State Long Beach


  • fol d
    fol d 5 days ago

    Meanwhile at a darpa underground lab been there done that

  • modolief
    modolief 5 days ago

    Wait, didn't I see this movie back in 1997? Yes, it was called Gattaca then.

  • Adil Hakim
    Adil Hakim 5 days ago

    Scishow You talk too fast. Slow down. The subject you're talking is quite advanced science and your youtube channel intention is to lay it out to us laymen, then do so without condescending us by talking fast as if we're stupid if we can't keep up!

    • Tdangerously
      Tdangerously 4 days ago

      I don't think Hank was trying to be condescending, that's just how fast he speaks. If you go in to the settings you can slow the video down, that may help.


  • Jozhua Mendoza
    Jozhua Mendoza 5 days ago

    Time for super powers or super human abilities.

  • austin bevis
    austin bevis 5 days ago

    Give me laser eyes with crispr

  • Patrick Hodson
    Patrick Hodson 5 days ago

    4:55 "the _Patrick_ of laws in other countries?"
    Ummm... _what?_ I've got nothing to do with those laws lol.

  • Melissa Clark
    Melissa Clark 5 days ago

    the 3Gbaby is 5 months old now....

  • Dellenite
    Dellenite 5 days ago +1

    Hank was a group of 8 cells at a stage of his life, someone should of disposed of him then

  • Sean Peery
    Sean Peery 5 days ago +1

    Privately funded research that suggest a gene altering technique that shows designer babies NOT begin a thing.
    Not to be conspiracy minded, but... that sounds like someone might be paying for some silence to keep poor people from trying to make designer babies by creating fake results.

  • Adithya Manivanan
    Adithya Manivanan 5 days ago

    Y not make inteligent donkays

  • Makishima Yusuke
    Makishima Yusuke 5 days ago +1

    Oh, the embryo does not allow changes to itself if both sides are removed? I wonder why it does that... 😑

  • SenseiRaichuss
    SenseiRaichuss 5 days ago

    Great news, nature > science.

  • BlueMushroom
    BlueMushroom 5 days ago

    Didn't China do this way before?

  • josh m
    josh m 5 days ago

    If the man will still have sperm with the disorder, even with crispr, than why mess around with genetic engineering. He could just get a sperm donor.
    It would produce the same results, and it keep the kid's DNA natural.

  • A. Nameline
    A. Nameline 5 days ago

    .....so what happened to the teeny tiny humans after that?

  • Scott Wood
    Scott Wood 5 days ago

    Won't this inhibit evolution? I'm just thinking big picture here...

  • Al Somethin
    Al Somethin 5 days ago

    I want to be modified and fixed Im a mutated mess!! I dont want to be better than everyone else just the best me that I can be instead of a mutant with blood cancer.

  • Nathan Burnett
    Nathan Burnett 5 days ago

    The flurries are probably enjoying themselves right now...

  • Gavin Harner
    Gavin Harner 5 days ago

    Thats funny how it was on aug 2 that is my birthday.

  • Larima Tolaganon
    Larima Tolaganon 5 days ago

    So, can this be used to assist cutting out genetic disorders for a healthier population? Because that would be amazing. Of course, now we have to be careful in continued research because genetic testing on babies tends to be taboo, as it should be for many reasons.

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    He is not expecting you to clean yourself, He will do it.

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  • Azio Prism
    Azio Prism 5 days ago +1

    *wealthy people gonna fund CRISPR until they get eternal life and wealth*

  • Azio Prism
    Azio Prism 5 days ago +2

    *can CRISPR like edit my DNA so that i am always a little high?*

  • Google made me do it

    Thank God for disliking vanity #godhatesbourgeoisie

  • Low Key
    Low Key 5 days ago

    I'm curious about something: could all these 'diseases' actually be mutations that have, in some way unknown to us, given us an advantage at some point during our evolution and could, in the future, protect us against whatever the environment throws at us? For instance, what if autism wasn't a disorder in some situations, but was rather an evolved advantage that suited a particular situation in our collective past? By editing out these mutations, maybe we're actually protecting ourselves from our protections?

    • Knight Robot
      Knight Robot 4 days ago

      Low Key ummm yes it does. With specialized jobs, modern medicine, etc everyone is allowed into the gene pool


    • Low Key
      Low Key 4 days ago

      Umm... evolution doesn't stop...


    • Knight Robot
      Knight Robot 4 days ago

      Low Key humans no longer evolve and we wouldn't need to. Also, Getting rid of autism for one generation doesn't mean It can't come back for another.


  • WatsonAndDaughter
    WatsonAndDaughter 5 days ago +1

    This stuff makes me feel sick.

  • Revanchist12
    Revanchist12 5 days ago

    Can this someday cure baldness?

  • medexamtoolsdotcom
    medexamtoolsdotcom 5 days ago

    So basically, if you try to replace a gene, it uses the same gene from the other chromosome instead of the one you try to implant. I guess I should give up on the dream of a genetically engineered race of catgirls then.

  • World Theory
    World Theory 5 days ago

    Progress in genetic engineering is more hope that we, as a species, will survive the effect that the act of saving people from illnesses with medical treatments, is having on our gene pool. Good thing that we know many ways that DNA is destroyed, and how it can be preserved. So if, in hundreds of years from now, we have only just perfected and made pratical, genetic engineering for near everyone, then we'll be able to introduce healthy DNA from a time period where modern medicine was only just beginning to be effective at preventing death. Because, it still wasn't that long ago, when doctors scoffed at the idea of washing their hands before helping to deliver a baby.

  • amber1322
    amber1322 5 days ago

    Amazing

  • surfergurl268
    surfergurl268 5 days ago

    if we stop any mutations then we stop evolution.... mutations can be good or bad, it's what drives evolution and variability.

  • HOOVER EVERYWHERE TM

    *Sierra 117*

  • Patrick Severance
    Patrick Severance 5 days ago +1

    Brave New World? Anyone? No? Then give my kid an IQ of 500 and make them bioluminescent..

  • Jakob Maier
    Jakob Maier 5 days ago

    please explain magnetic shielding

  • Dragonslayer Ornstein
    Dragonslayer Ornstein 5 days ago +1

    people who want to get rid of technology: CRISPR MUST DIE

    people who hate GMO's:KILL IT! ITS MORE POISON!

    me and people who like crispr:...YAY A POSSIBLE WAY TO KILL MALARIA! (and other diseases)

  • Lil Durk
    Lil Durk 5 days ago

    These niggas need to genetically engineer my bank account. Make those commas CRISPR

  • Ben Westbrook
    Ben Westbrook 5 days ago

    YOUTUBE needs to compile subject matter "TOPIC" playlists that can be filtered by language or just not make them

  • TheAwesomeGuy103
    TheAwesomeGuy103 5 days ago

    3:40 Pun intended?

  • Quantum Proton
    Quantum Proton 5 days ago

    I want to use Crisp to make a clone of myself, just to anger any religious people in my country

  • Angry Kittens
    Angry Kittens 5 days ago

    Designer babies is kinda pointless when the scope of this discovery gets fully exploited. Designer adults is where it's at. Fixing cancerous cells would be the most obvious and most needed of course, but the applications are enormous. We could start incorporating new gene snippets to make adults stronger or faster or taller or bluer... eventually maybe, immortality.

  • plnkfloydian
    plnkfloydian 5 days ago

    This lasagna looks crisp

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